Drs. Wang, Wu and Xu
The patient is a 65-year-old male; he was presented with polydipsia, polyphagia, and urorrhagia for the past 10 years. His body weight index is 11% over normal levels and he had the 3 typical symptoms and one insufficiency symptom for 4 months. Prior to admission, his blood sugar levels were monitored and the empty stomach blood sugar level was: 14.55mmol/L, the after meal blood sugar level was: 18.88mmol/L. He later went to the hospital and received the standard treatment for diabetes, but his blood sugar levels were still not under control.
Upon admission, stochastic blood sugar level: 15.6mmol/L, routine test for glucose levels in the urine (+++), ketone body (+), blood potassium: 3.25mmol/L; OGTT showed: Empty stomach blood sugar level: 6.59mmol/L, after meal blood sugar level: 16.93mmol/L, Glycolated hemoglobin: 12.5%. Ultrasonic examination showed: mild fatty liver. The blood vessel ultrasonic confirmed atherosclerosis. The neuroelectricity physiology showed diabetic peripheral nerve pathological change (mild), nail-fold micro cycle- light to moderate abnormality.
The patient was diagnosed with typeⅡ diabetes. Diabetic peripheral nerve pathological change; Fatty liver (mild); Atherosclerosis.
The patient received health education regarding diabetes. He also received information on proper nutrition and how to improve his diet, as well as advice on exercise. We will use a "composite treatment to protect the islet cells" and to control the disease, inject insulin with an insulin pump in order to control blood sugar density, then we will reduce the high sugar toxicity within the entire body, decreasing the harmful effects. The composite treatment method will improve the microcycle throughout the body. The nerve fiber excitability method together with the mesenchyma stem cell transplantation treatment will repair the damaged blood vessels, microcycle and the beta cells in the islands of langerhans. We will also adopt an individualized treatment plan to counteract any related complications.
The patient´s condition had good improvement after the systemic treatment. We adjusted the potassium levels in the blood, decreased the blood sugar levels, and corrected the ketone and the ketone body (-). The patient´s blood potassium level is normal. Upon admission, the dosage of insulin was as high as 39U. After the treatment, he has stopped using insulin, and only takes a small amount of medication to decrease the sugar density. The blood sugar level is between 4.4 - 6.2mmol/L and has been controlled. The patient will be making follow-up visits for half a year: He is completely willing to continue taking the small amount of required medications, following the strict diet and staying active in a sensible way to control his blood sugar levels. The patient´s body weight has been maintained at 70kg (standard body weight). He also controls the type of staple foods he eats. The patient´s blood sugar level on an empty stomach is 5.6mmol/l, after meal: between 5-6 mmol/l.
Diabetes is one kind of chronic body-wide immunity metabolic disease. There are two kinds of clinical diabetes, type 1 and type 2. People suffering from Type 1 diabetes comprise approximately 10% of the patient total number; their treatment must rely on insulin. People suffering from type 2 diabetes account for approximately 30% of the patient total number, they also need to rely on insulin treatment in later periods. Now, we introduce a stem cell treatment methods for type 2 diabetes. Type 2 diabetes is a polygenic and heredity disease. Its onset is dependent on several combined factors. With type 2 diabetes, either the pancreas does not produce enough insulin or the body’s cells cannot use the insulin adequately.
Studies conducted within recent years have indicated that the type 2 diabetic´s mechanism controlling blood sugar levels is elevated because of two aspects of metabolic blocking:
1. The pancreatic gland´´s beta cells are not functioning properly, and the number of beta cells may have largely been reduced (this is related to glucose or sugar fat toxicity) causing a decrease in insulin secretion.
2. The organs which are sensitive to insulin, such as the liver and muscles present the insulin resistance.
Research in the biomedical domain has confirmed that stem cell treatment has promising potential. When we transplant a certain amount of stem cells into the pancreas, they represent "seeds". These "seeds" will induce the splitting of multiple cells within the islands of langerhans within the pancreatic gland´s micro environment. Then these cells substitute damaged beta cells causing an increase of insulin to be secreted. This has overcome two problems: the donor insufficiency and the immunity repels and enhances the security greatly. Both domestic and international medical literature has confirmed that stem cell transplantation has a short-term curative effect. When a patient receives the stem cell transplantation treatment, they can stop using or reduce the amount of diabetic medication and the safety to their health is good, without any obvious complications or side effects.
The function of stem cells in the treatment of diabetes:
1. Stem cells substitute exceptionally for the dysfunctional beta cells, increase the cell quantity, enable the beta cells to restore function, enhance the sensitivity of beta cells to insulin so that the insulin secretion levels aren´´t too high or too low, and correct insulin paracrisis.
2. The stem cells can repair the post receptor defects of insulin. The stem cells which are implanted in vivo have normal gene expression. They can deliver large groups of normal working proteins, thus reducing the effects of insulin resistance proteins.
3. The stem cells can secrete large amounts of insulin type growth factor, and protect the pancreatic gland functioning.
For the stem cells to express their functions completely, the treatment must be handled by doctors with the most amount of clinical experience.