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Simone Fausto-Progressive spinal muscular atrophy-(Argentina)-Update on July 20th, 2017

Views Posted at 2014/01/14

Seventh round of treatment:

Name: Simone Fausto
Sex: Male
Nationality: Argentine
Age: 47Y
Diagnosis: Progressive spinal muscular atrophy (PSMA)
Date of Admission: May 18th, 2017
Treatment hospital/period: Wu Medical Center/26days

Before treatment:
Simone Fausto was present with motor disturbance of limbs and trunk 47 years ago, he went to the local hospital and diagnosed with spinal muscular atrophy. He was able to move his body, write and go to the bathroom himself before 11 years old, but 10 years after that, these abilities were gone. He was not able to hold up his trunk 9 years ago, he need something to support him when he sat. It was difficult for him to chew or swallow, he breathed and coughed hard, when he yelled, his voice was low and unclear. He was not able to move his limbs and trunk 6 years ago, he could hardly control his hear, he had difficult to breathe, chew or swallow, sometimes he chocked and spoke unclear. He comes to our center to have the stem cells treatment every year, after the treatments, his breath was better than before. The neck muscle was powerful, he was able to turn over his heard wider, especially to the right. He was able to open his elbow joints with someone’s help to 120 degrees. Both side fingers could move freely, the thumbs could move inside strongly and he was able to against part resistance. His left thumb and palm could hold a pen together. He took drugs and did the rehabilitation exercise regular. His neck was stronger, he didn’t need neck support anymore. He wanted a better treatment so he came to our hospital.
He is in good spirit, his diet, urination and defecation are normal. He put up some weight in one year.

Admission PE:
Temperature: 37.1℃, Hr: 92/min, Br: 20/min, Bp: 128/80mmHg. There was no pharyngeal congestion. The tonsils were not enlarged. The thorax was not symmetrical. The respiratory sounds in both lungs were clear butslightly lower than normal, with no obvious dry or moist rales. The heart sounds were lower, the cardiac rhythm was regular, with no obvious murmur. The abdomen was distended and soft, sounds liketympany and there wasno palpable mass.His both ankles and feet hadobvious concave edema.His four limbs were shorter than normal. The spinal column was bent to the right side. Both elbow joints and knee joints had contracture and were unable to straighten. The elbow joints could stretch to 85 degree angle passively. The knee joints could stretch to 120 degree angle passively.

Nervous System Examination:
Simone was conscious and alert. The calculation abilities, insight ability and orientation were normal. His speech was slurred. Both pupils were equal in size and round, the diameter was 3.0mms. Both eyeballs could move flexibly and the pupils reacted normally to light stimulus. There was no obvious nystagmus. The examination of the vision and visual field were normal, he was able to open mouth 1cm, he was able to put his tongue out of mouth about 2 cm. He had no teeth or mouth deflection. He had difficult to chew or swallow and he didn’t need neck support when he was standing. The muscle strength to neck was level 3- when he swivel to the left, the muscle strength of neck was level 3- when heto swivel to the right. The shrug shoulders action could been seen. The muscle strength of both upper limbs’ proximal-end was level 0.When he raised his upper limbs over his head, the left thumb adductor and abductor muscle power was at level 3-, the left index finger was at level 1, the right thumb adductor and abductor muscle power was at level 2,the right index finger was at level 1-2, the muscle power of other fingers were all at level 0. The muscle strength of both lower limbs’ proximal-end was level 0. All toes had slight plantar flexion butdorsi flexion ability was not obvious to see. There was muscle atrophy in all four limbs, shoulder girdle and trunk. The muscle tone of all four limbs was reduced. The abdominal reflexes and tendon reflexes of all four limbs were disappeared. The bilateral palm jaw reflex was negative. The grasping reflex was negative. The bilateral Hoffmann’s sign was negative. The bilateral Babinski’s sign was negative. The sensory examination results were normal. Simone was not able to cooperate with the coordinated movement examination.

Treatment:
After the admission, he received related examinations and diagnosed with PSMA. He received 4 neural stem cell injections and 4 mesenchymal stem cell injections to repair his damaged nerves, replace dead nerves with new injected stem cells, nourish nerves, regulate his immune system and improve blood circulation, with rehabilitation training.     

Post-treatment:
After 26 days’ treatment, his breath was better than before, his heart and lung function were stable. His breath sounds of both lungs were clearer than before. He could speak better and clear, he could speak in loud. The muscle power of head and neck are improved to level 3, he could keep head in right position. His upper limbs are flexible, his left wrist bending action could be completed under the specific position. The both hands’ kneading muscle power of thumb and index finger was better than before. He could hold a pen. The muscle power of lower limb was improved, he could move knees, ankles and toes better. His toe could do dorsiflexion and planter flexion.


Date of Admission: April 17, 2016
Treatment hospital/period: Wu Medical Center/26 days

Before treatment:
Simone Fausto was diagnosed with spinal muscular atrophy 46 years ago He was able to move his body, write and go to the bathroom by himself before he was 11 years old, but 10 years after that, these abilities were gone. He was not able to hold up his trunk 9 years ago and he needed support when he sat down. It was difficult for him to chew or swallow, he breathed and coughed hard. When he yelled, his voice was low and unclear. He was not able to move his limbs or trunk 5 years ago. His hearing ability had diminished. Sometimes he chocked and spoke unclearly. He came to our center for stem cell treatment every year and after the treatments, his breathing had improved. The neck muscles were powerful and he was able to turn his head flexibly both ways, but especially to the right. He was able to open his elbow joints with someone’s help to 120 degrees. The fingers on both hands could move freely, the thumbs could move inwards strongly and he was able to push against some resistance. His left thumb and palm could hold a pen. He was prescribed medication and did the rehabilitation exercises regularly. His neck was stronger and didn’t need support anymore. Simone wanted a better treatment option, so he came to our hospital. He was in good spirits, his diet, urination and bowel movements were normal.

Admission PE:
Temperature: 35.8℃, Hr: 64/min, Br: 19/min, Bp: 123/74mmHg. There was no pharyngeal congestion. The tonsils were not enlarged. The thorax was not symmetrical. The respiratory sounds in both lungs were clear but slightly lower than normal, with no obvious dry or moist rales. The heart sounds were lower; the cardiac rhythm was regular, with no obvious murmur. The abdomen was distended and soft, with tympanic sounds. There was no palpable mass. All four limbs were shorter than normal. The spinal column curved to the right side. Both elbow joints and knee joints had contracture and were unable to straighten. The elbow joints could stretch to a 90 degree angle passively. The knee joints could stretch to a 120 degree angle passively.

Nervous System Examination:
Simone was conscious and alert. The calculation abilities, insight ability and orientation were normal. His speech was slurred. Both pupils were equal in size and round, the diameter was 3.0mms. Both eyeballs could move flexibly and the pupils reacted normally to light stimulus. There was no obvious nystagmus. The examination of the vision and visual field were normal. Simone was able to open his mouth 1cm; he was able to extend his tongue outside his mouth about 1 cm, there was no deflection of the teeth. He had difficulty chewing or swallowing. He didn’t need neck support when he was standing. The muscle strength of the neck was level 2- when he swiveled to the left; the muscle strength of the neck was level 3- when he swiveled to the right. The shrugging strength of the shoulders was weak. The muscle strength of both upper limbs’ proximal-end was level 0. When he raised his upper limbs over his head, the left thumb adductor and abductor muscle power was at level 3-, the left index finger was at level 1, the right thumb adductor and abductor muscle power was at level 2, the right index finger was at levels 1-2, the muscle power of the other fingers were all at level 0. The muscle strength of both lower limbs’ proximal-end was level 0. All the toes had slight dorsiflexion but the plantar flexion ability was not obvious to see. There was muscle atrophy in all four limbs, shoulder girdle and trunk. The muscle tone of all four limbs was reduced. The abdominal reflexes and tendon reflexes in all four limbs were diminished. The bilateral palm jaw reflex was negative. The grasping reflex was negative. The bilateral Hoffmann’s sign was negative. The bilateral Babinski’s sign was negative. The sensory examination results were normal. Simone was not able to cooperate with the coordinated movement examination.

Treatment:
Simone received related examinations and was diagnosed with progressive spinal muscular atrophy (PSMA), so he received four neural stem cell injections and four mesenchymal stem cell injections to activate the new stem cells, repair the damaged cells, improve the immune system function, improve the blood circulation in order to increase the blood supply to the damaged neurons and nourish them. He also had rehabilitation training.

Post-treatment:
Simone’s breathing was better than before, his heart and lung function were stable. The muscle power of both hands was higher. When he put both hands on his head, his grip was better than before, when the doctor regulated his left wrist, he was able to bend it. The thumbs’ adductor and abductor muscle power was at level 3, the muscle power of the right index finger was at level 2-, the left index finger was at level 2. The muscle power of the other fingers was at level 1.

E-mails:

Date:2016-7-14

Dear doctors in the attachement I send you report the fausto's blood.
Fausto is very very good.  Your general condition is perfect.
He is taking all rehabilitations therapis.
The weight, height, appetite,  sleep and bowel movements are very good and strong.
The bood pressure and heart rate is perfectly normal.
He use all night the non invasive  ventilator.  Your oxygen saturation is 96 - 97.
Best regards,
Ann

Date:2016-12-2

Dear Dr. Liu I'm Ana, the Fausto's wife.
Fausto is very very good thank's to God.
Your general condition including Height, Weight, appetite, sleep and Bowel movements is perfect.
The Fausto's blood pressure is 110/60 regulary.
He take all medication and make all days the rehabilitation training.
The Fausto's finger-tip blood axygen saturation is arround 98%.
In the attachment I send you blood routine of the July months. 
If you need a new routine blood, please say me.
Best regards,
Ana

 

 


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The patient is able to move his neck better without neck support.

Date:2016-7-25

Dear doctors in the attachement I send you report the fausto's blood.
Dear Doctors want to tell that Fausto can turn himself in bed. When side in bed , he can return to position itself faceup.
We are very very happy.
THANK YOU FOR GIVING US HOPE
Ana and Fausto

Name: Simone Fausto
Sex: Male
Country: Argentina
Age: 41
Diagnoses: Progressive spinal muscular atrophy (PSMA), HHCY -hyperhomocysteinemia
Admission Date: 2011-05-30
Days Admitted to the Hospital: 32

Simone had a movement disorder in the trunk and limbs and was diagnosed with spinal muscular atrophy at the local hospital. He was able to move his limbs freely before he was 11 years old and could perform simple activities of daily life. There was a gradual decline in motor functioning in the last 10 years and Simone was eventually unable to support his body, beginning about 5 years ago, and he needed the assistance of a bracket to maintain a sitting position. Chewing and swallowing became difficult and breathing required more effort. His ability to cough was weak and his speech was slurred. The four limbs had no movements. Simone also had difficulty controlling the movements of his head. Because he hadn't received effective treatment in Argentina, so he looked therapy in all over the word and decided to Wu Stem Cells Medical Center for treatment.When Simone first arrived at our medical center, there was no breakage or hemorrhagic spots on the skin. The thorax was not symmetrical. He had difficulty breathing. The respiratory sounds in both lungs were clear. The cardiac rhythm was regular, with no obvious murmur. The abdomen was distended and soft, with no palpable masses. The elbows are flexed and cannot stretch. The spinal column curves to the right. The forearms could bend to a 90 degree angle with the upper arms when passively stretched.Throughout the examination of the nervous system, Simone was conscious and alert. His calculation abilities and orientation were normal. His speech was slurred. The examination of the vision and visual field was normal. The neck muscles were weak and he had poor control over the movements of his head and could not move the head flexibly. The muscle strength of both upper limbs' proximal-end was level 0. The fingers of both hands had slight movement but couldn't grasp any objects. The muscle strength of both lower limbs' proximal-end was also level 0, and only had slight activity. There was muscle atrophy in the upper limbs, lower limbs, shoulder girdle and torso. The muscle tone of all four limbs was reduced. The tendon reflexes of all four limbs were diminished.

Treatment:
The patient received treatment to improve the blood circulation in order to increase the blood supply to the damaged neurons and nourish them. At the same time, we brought the cardiac rate under control. He was also received treatment for neural activation and nerve regeneration. This was accompanied with daily physical rehabilitation training to promote the recovery of the motor functioning.

After treatment:
After the completion of the treatment, Simone's cardiac rate was slightly lower. Breathing no longer takes so much effort. The muscle strength of the neck has increased. The range of movement of the neck from side to side has improved; he can turn his head to the right side easier. Both elbow joints can bend the forearms to the upper arms, to a 110 degree angle. The range of motion of the fingers has increased. The adduction movement strength of the thumbs has increased, and both thumbs can push against partial resistance. The adduction movement strength of the left thumb has improved to the point where it can hold a pen against the palm.

Second round of treatment:
Admission Date: 2012-04-16
Days Admitted to the Hospital: 26
About 1 year ago, Simone came to Wu Stem Cells Medical Center for treatment. After the treatment plan was completed his breathing range of motion had improved. The muscle strength of the neck had increased and the neck could be turned to a further degree to the left and to the right. The elbows are able to flex the forearms to a 110 degree angle with the upper arms. The range of movement of the fingers of both hands has increased. The thumbs are able to push against some resistance. The left thumb can hold a pen against the palm. After being discharged after the first round of treatment, Simone was prescribed oral medication and will continue with the physical rehabilitation training. Simone returned to Wu Stem Cells Medical Center for the second round treatment.

Admission PE:
The skin was normal, with no breakage or hemorrhagic spots. The thorax was not symmetrical. The respiratory sounds in both lungs were clear, with no dry or moist rales. The thoracic expansion was good. The heart sounds were blunt; the cardiac rhythm was regular, with no obvious murmur. The abdomen was distended and soft, with no palpable masses. The limbs are shorter than normal. The spinal column is bent to the right side, but can stretch about 7 cm's further than last year. Both elbow joints and knee joints had contracture and were unable to straighten outward. The elbow joints could stretch to a 90 degree angle passively. The knee joints could stretch to a 120 degree angle passively.

Nervous System Examination:
Simone was conscious and alert. The calculation abilities, insight ability and orientation were normal. The speech was slurred. Both pupils were equal in size, the diameter was 3.0mms. Both eyeballs could move flexibly and the pupils reacted normally to light stimulus. There was no nystagmus. The examination of the vision and visual field were normal. The neck muscles were weak. The muscle strength to swivel to the left was level 2; the muscle strength to swivel to the right was level 3. The shoulders couldn't be shrugged. The muscle strength of both upper limb' proximal-end was level 0. Both thumbs had adduction movement ability and the muscle strength was about level 2. The little finger of both hands was unable to move. The other fingers had slight movement. The muscle strength of both lower limbs' proximal-end was level 0; both feet had slight dorsiflexion and plantar flexion ability. There was muscle atrophy in all four limbs, shoulder girdle and trunk. The muscle tone of all four limbs was reduced. The abdominal reflexes and tendon reflexes of all four limbs were diminished. The bilateral palm jaw reflex was negative. The grasping reflex was negative. The bilateral Hoffmann's sign was negative. The bilateral Babinski's sign was negative. The sensory examination results were normal. Simone couldn't cope with the coordinated movement examination.

Treatment:
The patient received treatment to improve the blood circulation in order to increase the blood supply to the damaged neurons and nourish them. At the same time, we brought the cardiac rate under control. He was also received treatment for neural activation and nerve regeneration. This was accompanied with daily physical rehabilitation training to promote the recovery of the motor functioning.

Post-treatment:
During the treatment, the patient had no infections. The adduction strength of the thumbs increased. The left thumb has some resistance ability and the muscle strength of the left thumb is about level 3. The left thumb can point thumb with forefinger, middle finger and the ring finger. The muscle strength of the right thumb is about level 3-, and is able to point to the forefinger. The other four fingers can only slightly grasp objects.

Third round of treatment:
Admission Date: 2013-03-24
Days Admitted to the Hospital: 26

The patient received second round treatment in our hospital. After treatment, the patient's condition was stable and not aggravated. For further treatment, the patient went to our hospital again.

Nervous System Examination:
Simone was conscious and alert. The calculation abilities, insight ability and orientation were normal. The speech was slurred. Both pupils were equal in size, the diameter was 3.0mms. Both eyeballs could move flexibly and the pupils reacted normally to light stimulus. There was no obvious nystagmus. The examination of the vision and visual field were normal. The neck muscles were weak. The muscle strength to neck was level 2- when he swivel to the left; the muscle strength of neck was level 3- when he to swivel to the right. The shrug shoulders action was not good. The muscle strength of both upper limbs' proximal-end was level 0. Only the thumb of left thumb had slight adduction movement.The right hand's fingers had slight bend action. The muscle strength of right hand's fingers was about 1-2 levels. Both hands couldn't grasp. The muscle strength of both lower limbs' proximal-end was level 0; All toes had slight dorsiflexion and plantar flexion ability. There was muscle atrophy in all four limbs, shoulder girdle and torso. The muscle tone of all four limbs was reduced. The abdominal reflexes and tendon reflexes of all four limbs were disappeared. The bilateral palm jaw reflex was negative. The grasping reflex was negative. The bilateral Hoffmann's sign was negative. The bilateral Babinski's sign was negative. The sensory examination results were normal. Simone couldn't cope with the coordinated movement examination.

Treatment:
According to the patient's medical history and related examination. The patient was diagnosed with progressive spinal muscular atrophy (PSMA) clearly. He received treatment to improve the blood circulation in order to increase the blood supply to the damaged neurons and nourish them. At the same time, we brought the cardiac rate under control. He was also given treatment to adjust the immunity of the organism and nerve regeneration. This accompanied with daily physical rehabilitation training to promote the recovery of the motor functioning.

Post-treatment:
The adduction muscle strength of left thumb is level 3. The adduction muscle strength of right thumb is level 3-. Other fingers of right hand has obvious slight grasp ability. He is able to take deeper breathe. The heart sounds are much stronger than before. The muscles in the feet are much stronger and able to complete the dorisflex and plantar flexion action.

Fouth round of treatment:

Date: Apr. 5th, 2015
Days Admitted to Hospital: 26 days

Before treatment:
The patient had dyskinesia of the limbs and trunk 45 years ago and was diagnosed with spinal muscular atrophy. He could move his body; he could write and go to the bathroom himself before 11 years old. 10 years after that, his ability to do the daily activities was gone. He couldn’t hold up his trunk 9 years ago. He needed something to support him when he sat. He had difficult to chew and swallow 8 years ago. He breathed and coughed hard. When he yelled, his voice was lower and unclear than before. He couldn’t move his limbs and trunk 4 years ago. He couldn’t control his head. Had difficult to breathe, chew and swallowed, sometimes he chocked and his speech was unclear. He had come to our hospital 3 times. After the treatment, his breath was better than before. The neck muscle was powerful; he could turn over his heard wider, especially to the right. He could open his elbow joints with someone’s help to 110 degree. Both fingers could move freely. The thumbs could move inside strongly. His left thumb and palm could hold a pen together. He took drugs and did the rehabilitation exercise regularly. The neck was stronger; he didn’t need neck support anymore. He wanted a better treatment so he came to our hospital.

He was in good spirit. His diet, urination and defecation were normal. His weight was same in 4 years.

Admission PE:
Temperature: 36.0 degree, Hr: 70/min, Br: 18/min, Bp: 124/86mmHg. The skin was normal, with no breakage or hemorrhagic spots. The thorax was not symmetrical. The respiratory sounds in both lungs were slightly low, with no obvious dry or moist rales. The heart sounds were low; the cardiac rhythm was regular, with no obvious murmur. The abdomen was distended and soft, with no palpable masses. The limbs were shorter than normal. The spinal column was bent to the right side. Both elbow joints and knee joints had contracture and were unable to straighten. The elbow joints could stretch to an angle of 90 degrees passively. The knee joints could stretch to an angle of 120 degrees passively.

Nervous System Examination:
Simone was conscious and alert. The calculation abilities and orientation were normal. The speech was slurred. Both pupils were equal in size, the diameter was 3.0mms. Both eyeballs could move flexibly and the pupils reacted normally to light stimulus. There was no obvious nystagmus. The examination of the vision and visual field were normal. He could open his mouth 1.5cm. He could put his tongue out of the mouth about 0.5 cm. He had no teeth deflection. He had difficult to chew and swallow. He could control his head better than last year and he didn’t need neck support when he was standing. The muscle strength to neck was at level 2- when he swivel to the left, the muscle strength of neck was at level 3- when he swivel to the right. The shrug shoulders action was not good. The muscle strength of both upper limbs’ proximal-end was at level 0. The left thumb adductor and abductor muscle power was at level 3-. The right thumb adductor and abductor muscle power was at level 2. The muscle strength of finger’s of both hand’s was at level 1. The muscle strength of both lower limbs’ proximal-end was at level 0. All toes had slight dorsiflexion and plantar flexion ability. There was muscle atrophy in all four limbs, shoulder girdle and torso. The muscle tone of all four limbs decreased. The abdominal reflexes and tendon reflexes of all four limbs disappeared. The bilateral palm jaw reflex was negative. The grasping reflex was negative. The bilateral Hoffmann’s sign was negative. The bilateral Babinski’s sign was negative. The sensory examination results were normal. Simone couldn’t cope with the coordinated movement examination.

Treatment:
The patient was clearly diagnosed with progressive spinal muscular atrophy (PSMA). He received treatment to improve the blood circulation in order to increase the blood supply to the damaged neurons and nourish them.

Post-treatment:
His breath was better than before. He could swallow easily. He also could speak more clearly. He didn’t have expectoration. His exercise tolerance was better. The muscle power of both hands was higher. When he put his hands on his head, palms-up on the bed, his grip was better than before. The treatment plan has been completed and the discharge has been permitted.

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Simone Fausto's wife is playing the flute for the medical staffs.

 

 


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