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New Hope for Brain and Spinal Cord Injury Patients

Author Admin Views Posted at 2013/12/28

Nov, 2008, by Dr.Like Wu

How neurocytes regenerate and differentiate. 
Central Nervous System diseases and injuries involving the brain and spinal cord are most common.  These conditions cause some of the highest incidence of mutilation of neurocytes.  In the past with the thinking that neurocytes could not regenerate patients with neurocyte injury and/or those patients with graduate mutilation conditions were left alone and untreated.  In the past 10 years, however, research has found, in adult models, that there are some primordial neurocytes, precursor cells and astrocytes located in the inferior region of the lateral cerebral ventricles and cornu ammonis.  When human bodies are under certain special pathophysiological conditions the first two cell types mentioned can undergo the process of neurogenesis; regenerating and differentiating.  In addition an astrocyte can degenerate into a protocell.  These cells can then regenerate and differentiate into types of cells needed by human body.  This research thoroughly overthrows the opinion that neurocytes cannot regenerate and this turn of events provides a new treatment chance for patients with CNS injury.
When can neurocytes regenerate and differentiate?
According to the theory of the neuro-endocrine-immune network, we know that under certain special pathophysiological conditions the endocrine and immune circulation of neurocytes in human body intra - cerebrum will have corresponding changes.  It is just these types of microenvironmental changes that induce neurocytes into regeneration (replication) and a subsequent differentiation phase.
Nerve stem cell mobilization techniques are used in clinical practice.
Based on the above theory by imitating the microenvironments thus facilitating neurocyte regeneration and differentiation utilizing the technique of adult nerve stem cell mobilization, which is the core of a recently developed post CNS disease and injury treatment program, we can improve the life quality of these patients.  This in turn brings hope to the patients that they might be able to return to their families and participate again in society.  The final objective of this treatment regimen is to facilitate CNS cellular replacement and/or enable the remaining nervous system to fully play its role.  In short the technique is attempting to bring reserved neurocytes and/or neurocytes in quiescent conditions into full play thus rebuilding the neural network and achieving a functional regrouping.
Further brain and spinal cord plasticity research indicates that most post CNS injury patients in stable stage or sequelae stage still have chance to recover.  Recent research fully indicates that other types of cells can replace the injured cells.  The CNS can achieve that efficacy through nerve circuit loop regeneration and/or by strengthening the connections between synapsises.  I have noted over my years of clinical practice that with motor function therapy paralysis patients have recovered at different levels.  The foundation of this treatment regimen is that stem cells can convert.
The basic structure of this method is ´medicine mobilization + biofeedback + comprehensive rehabilitation.  It is based on the ´´neuro-endocrine-immune network´´ theory.  We treat patients, ensuring excellent safety standards, using a chemically derived product to create the desired tissue environment for optimum regeneration.  In addition we alter the neuro-endocrine (growth factor and insulin-like nutrition factor) and the immune status (tumor necrosis factor and interleukin) to meet our desired outcome.   All of this is then assisted by a comprehensive nerve rehabilitation treatment thus mobilizing already-existing adult nerve stem cells in CNS.  To achieve full regeneration, differentiation, facilitation and rehabilitation with signal induced medicine we convert adult nerve stem cells into cells with specific functions such as neurocytes, gliacytes and oligodendroglia.  If patients do not have enough already-existing adult stem cells we can use the nerve stem cell transplantation technique.  By employing all of the above methods we can maximally improve functions for the afflicted individual such as sensibility, mobility, language and intelligence. 
The key to the success of this treatment method is the overall customized treatment regimen for each patient.  The core part of the entire treatment regimen is based on a thorough nerve system function evaluation of stable post CVD patients and post injury patients in the sequelae stage.  Currently, in both foreign countries as well as in China, this treatment regimen has been used for numerous diseases such as; stroke, acute myelitis, motor neuron disease, Parkinson´s syndrome and craniocerebral trauma.  In addition for spinal cord injuries, it has been combined with surgery to treat hemiparalysis, paraplegia, tetraplegia, dysmoytonia, linguistic functional disturbance, dysphasia, neurogenic bladder and rectal functional disturbances.  In many developed countries this type of treatment has been used for these issues in both acute and stable stages and has been noted to accelerate the recovery speed for patients. In our country, due to the restriction of various conditions, it is mainly used for patients with a shorter than one year history of post CVD at sequelae stage. 
Dr. Like Wu; Dr.Xiaojuan Wang 
Chief doctor of Beijing Neural Stem Cell Therapy Center
(Translated from Chinese)
Edited by Kirshner Ross-Vaden RN
(Novembe, 2008)



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