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Umbilical cord blood mesenchymal stem cell transplantation in 20 patients with multiple system atrophy

Author Admin Views Posted at 2013/12/28

Dec 08, 2009 by Wu like

Umbilical cord blood mesenchymal stem cell transplantation in 20 patients with multiple system atrophy
Wu Like, Wang Xiaojuan,Xu Baolei, Liu Shuangshuang,Chu Saichun,Cheng Bo
Beijing Wu Stem Cells Medical Center, Beijing China 100070
Abstract
OBJECTIVE: To observe the outcomes of umbilical cord blood mesenchymal stem cell transplantation for treating neural function of multiple system atrophy (MSA) patients.
METHODS: A total of 20 MSA patients were selected at the Beijing Wu Stem Cells Medical Center from January to October 2008. All patients received treatment of vessel distention, anti-free radical, trophic nerve and cell membrane stabilization, as well as umbilical cord blood mesenchymal stem cell transplantation intrathecal injection. Patients at left-lateral position, and body bent at hips, knees and necks. Acupuncture was conducted at the space of lumbar vertebra 3 and 4. Following local anesthesia, No. 9 needle was directly pricked into the subarachnoid cavity. 2 mg dexamethasone was slowly infused, and 5 mL (5×106 stem cells) umbilical cord blood mesenchymal stem cell injection was obtained and slowly infused into the subarachnoid cavity within 10 minutes, once per week, four times as a course, totally one course. We adopted Unified Multiple System Atrophy Rating Scale (UMSARS) to evaluate those MSA patients. The higher score represented a severe pathogenetic condition. RESULTS: Compared with pretransplantation, the UMSARS score was significantly decreased in 20 patients 4 weeks following transplantation ( < 0.01). After the treatment, patient´s clinical symptoms such as slow movement, balance disturbance, orthostatic hypotension, urinary and bowel disorders had full obvious improvement. Graft versus host disease was not found. CONCLUSION: It is indicated that mesenchymal stem cell transplantation is effective, can partly improve MSA patients´ clinical symptoms, and improve patients´ life quality.

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