Multiple System Atrophy(MSA)
by Drs.Like Wu, Xiaojuan Wang and Bo Cheng
Classification of disease
MSA includes Shy-Drager syndrome (SDS), striatonigral degeneration (SND) and Olivopontocerebellar astrophy (OPCA), 3 types. According to the clinical manifestation, it can be classified into 2 kinds of clinical subtypes, 1 clinical subtype, Parkinson syndrome as main clinical manifestation is called MSA-P type, the other clinical subtype, cerebellar ataxia as main clinical manifestation is called MSA-C type.
The cause and Pathogenesis
The cause of the disease is not clear. The pathological symbol of MSA is that the eosinophilic inclusion body can be found in the cytoplasm of the neuroglia cell with the neuron losing and gliacyte hyperplasia.
Adult-onset, many patients had MSA whose ages are from fifty to sixty years old, the average age of patients at the onset of the disease is 54.2 years old. The morbidity of male is higher than female. The disease onset is slow and progresses gradually. First symptoms of MSA are the autonomic nerve dysfunction, Parkinson´s syndrome and cerebellar ataxia. A few patients also have an onset with amyotrophy.
Regardless of the start of the disease, with what kind of nervous system symptoms, when the disease progresses further, there will be two or more systematic neural symptoms group following:
1. Autonomic dysfunction
2. Parkinson syndrome
3. Cerebellar ataxia
The conventional treatment mainly includes symptomatic treatment and rehabilitation therapy but they are not shown to be effective. All kinds of medication therapy cannot hold back the degeneration and necrosis of the neurons and oligodendrocytes. In recent years, WSCMC found that the treatment of supplying neural stem cells, to directly increase the quantity of the neural cells in brain and repair the neural damage partly, while the neural stem cells carry normal genes, they can express normal functions and produce proteome following the proper medication controlling, those proteins with normal structures can replace the functions of abnormal proteins caused by the patients gene mutation, and decrease the quantity of accumulation inside gliacyte cytoplasm. It can partly restore neural functions; slow down the disease progress for MSA, Parkinson´s disease, dementia with Lewy bodies, and a series of the degenerative diseases. But it only leads to 10% of the cells survival; the neural stem cells are injected without the proper medication guideline, while the cells location is probably difficult. Based on almost a 10-year research, WSCMC has a unique implanted stem cell location technology and adjusting technology in vivo, which can obviously increase the function level of the location and differentiation and activation of the implanted stem cells in vivo, so that leads to target the effective treatment, improve the patients´ life quality and the implanted cells survival period.